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The Enoch Pratt Free Library is the free public library system of Baltimore, Maryland. Its Central Library and office headquarters are located on 400 Cathedral Street (southbound) and occupy the northeastern three quarters of a city block bounded by West Franklin Street (U.S. Route 40 westbound) to the north, Cathedral Street to the east, West Mulberry Street (U.S. Route 40 eastbound) to the south, and Park Avenue (northbound) to the west. Located on historic Cathedral Hill, north of downtown, the library is also in the Mount Vernon-Belvedere-Mount Royal neighborhood and cultural and historic district.

The Cathedral Street Main Library is the flagship of the entire Enoch Pratt Free Library system, now with twenty-two community / neighborhood and regional branches, it was designated the "Maryland State Library Resource Center" by the General Assembly of Maryland in 1971. The center operates as the state library for Maryland. A state agency oversees the center.