| Electric Drones In the Service | Academic & Science |
| Electronic Data Information Source | Academic & Science |
| Electronic Declaration Information System | Academic & Science |
| Environmental Data and Information Service | Academic & Science |
| Electronic Distributorless Ignition System | Business |
| Emergency Digital Information Service | Business |
| Employer Driven Insurance Services | Business |
| electronic Delivery Instruction Slip | Business |
| Earth Search Sciences, Inc. | Business |
| Educational and Developmental Intervention Service | Community |
| Educational Developmental Intervention Services | Community |
| Engineering Development Integration and Sustainment | Community |
| Economic Development Information System | Community |
| Educational and Developmental Intervention Services | Community |
| Electronic Document Information System | Computing |
| Extension Digital Information Source | General |
| Extension Data Information Source | General |
| Emergency Digital Information System | General |
| Electronic Direct Ignition System | General |
| Electronic Documentation and Information System | General |
| Emergency and Disaster Information Service | General |
| Emergency Department Information Systems | General |
| Every Day Is Saturday | General |
| Enterprise Data Integration Services | General |
| Email Data Input System | General |
| Emergency Department Information System | Governmental |
| Emily Dickinson International Society | International |
| Equipo De Investigaciones Sociológicas | International |
| Electronic Drug Information Systems | Medical |
| Elderly Diabetes Impact Scales | Medical |
| European Distributors of Industrial Supplies | Regional |
| European deposit insurance scheme | Regional |