| University of Puget Sound | Academic & Science |
| Ubiquitin/Proteasome System | Academic & Science |
| Université Paul Sabatier | Academic & Science |
| Universal Polar Stereographic | Academic & Science |
| University Policy Statement | Academic & Science |
| Uriahs Pony Service | Business |
| United Pediatric Services | Business |
| United Parcel Service, Inc. | Business |
| United Produce Service | Business |
| Unplanned stops | Business |
| Universal Player System | Community |
| Unity Peace Serenity | Community |
| United Pop Stars | Community |
| Universal Port Serial | Computer Hardware |
| Unit Power Supply | Computer Technology |
| User Profile Store | Computing |
| Unix Product Support | Computing |
| Unified Parallel Software | Computing |
| Uninterruptible Power System | Computing |
| Utility Pricing Solutions | Computing |
| User Provided Service | Computing |
| Unified Presence Server | Computing |
| Ultra Power Saver | Computing |
| Uplink Product Support | Computing |
| UPFI Network | Cryptocurrency |
| Un-interrupted Power Supply | Electrical Device |
| Universal Power Supply | Electronics |
| Unilateral Phase System | Electronics |
| Ultraviolet Photoelectron Spectroscopy | Electronics |
| Uniterruptible Power Supply | Electronics |
| Ultra Poor Service | General |
| Unbelievably Ponderously Slow | General |
| Unmitigated Package Smashers | General |
| Unbelievably Poor Service | General |
| Universally Poor Service | General |
| Un-Predictable Service | General |
| Use Purolator Service | General |
| Unusual Pulling System | General |
| Unequaled Package Smashers | General |
| Un-Prepared Speaking | General |
| Unusually Poor Satanosphere | General |
| Useless Power Supply | General |
| Unbelievably Pathetically Slow | General |
| Unbelievably Pulverized Shipments | General |
| Unreliable Postal Service | General |
| Unsatisfactory Poor Service | General |
| Universal Packing System | General |
| Useless Parcel Service | General |
| Under Paid Slaves | General |
| Uninterruptible Power Supplies | General |
| Uncommonly Poor Service | General |
| Unparalleled Pooch Surveillance | General |
| Useless Poor Service | General |
| United Pie Stands | General |
| Uninterruptible Power Source | General |
| Uninterupted Power Supply | General |
| Utter Parcel S*** | General |
| United Problem Solvers | General |
| Uninterrupted power source | General |
| Uninterrupted Power Supplies | General |
| Undelivered Parcel Service | General |
| Using Professional Sound | General |
| Uniform Power Storage | General |
| Unintentional Power Supply | General |
| Utter Parcel Sh*t | General |
| Ultimate Plane Service | General |
| Undoubtedly Pretty Slow | General |
| Unit Pump System | General |
| Umdrehungen Pro Sekunde | General |
| United Postal Service | Governmental |
| Uninterruptible Power Supply | Information Technology |
| Under-paid Slave | Jobs |
| Updates Per Second | Measurement Unit |
| United Parcel Service | Military and Defence |
| Unusual Points Situation | Military and Defence |
| Usually Pretty Slow | Networking |
| User Profile System | Networking |
| Ultra Perfect Service | Networking |
| Unintentional Packet Switch | Networking |
| Upright Perigee Stage | Space Science |
| Un-interruptable Power Supply | Telecommunication |