What is the difference between linear and convergent synthesis?
Career Talk Work & Career 2 years ago
Posted on 16 Aug 2022, this text provides information on Work & Career related to Career Talk. Please note that while accuracy is prioritized, the data presented might not be entirely correct or up-to-date. This information is offered for general knowledge and informational purposes only, and should not be considered as a substitute for professional advice.
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Best Answer
2 years ago
In chemistry a convergent synthesis is a strategy that aims to improve the efficiency of multistep synthesis, most often in organic synthesis. In this type of synthesis several individual pieces of a complex molecule are synthesized in stage one and then in stage two these pieces are combined to form the final product. In linear synthesis the overall yield quickly drops with each reaction step: Suppose the yield is 50% for each reaction, the overall yield of D is only 12.5% from A. In a convergent synthesis A-B (50%) C-D (50%) B + D-E (25%) The overall yield of E (25%) looks much better. Convergent synthesis is applied in the synthesis of complex molecules and involves fragment coupling and independent synthesis.