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duPont Manual High School is a public magnet high school located in the Old Louisville neighborhood of Louisville, Kentucky, United States. It serves students in grades 9–12. It is a part of the Jefferson County Public School District. DuPont Manual is recognized by the United States Department of Education as a Blue Ribbon School.

Manual opened in 1892 as an all-male manual training school. It was the second public high school in Louisville. Manual merged with its rival, Male High School, into a consolidated school from 1915 to 1919. Manual permanently merged with the Louisville Girls High School in 1950 and moved into their Gothic-style three-story building, built in 1934. In 2004, after conducting a poll, Louisville's Courier-Journal newspaper listed Manual as one of Louisville residents' ten favorite buildings. Manual experienced a decline in discipline and test scores in the 1970s. In 1984, Manual became a magnet school, allowing students from throughout the district to apply to five specialized programs of study, or magnets.

Manual and Male High School have the oldest football rivalry in the state, dating back to 1893. Manual's football team has won five state titles and claims two national championships. In the 1980s and 1990s Manual became a prominent academic school and has been included several times in lists of America's top high schools in Redbook and Newsweek magazines. The high school has been recognized as a Perennial Top Academic School in Kentucky and holds the most national merit semi-finalists among all JCPS High Schools.