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Case Western Reserve University (CWRU) is a private research university in Cleveland, Ohio. Case Western Reserve was established in 1967, when Western Reserve University, founded in 1826 and named for its location in the Connecticut Western Reserve, and Case Institute of Technology, founded in 1880 through the endowment of Leonard Case, Jr., formally federated. Case Western Reserve joined the Association of American Universities in 1969.

Case Western Reserve undergraduate and graduate schools include the College of Arts and Sciences, Case School of Engineering, Mandel School of Applied Social Sciences, Case Medical School, Weatherhead School of Management, Case School of Dental Medicine, School of Law, and Frances Payne Bolton School of Nursing. Its main campus is approximately 5 miles (8 km) east of Downtown Cleveland in the neighborhood known as University Circle, an area containing many educational, medical, and cultural institutions. Case Western Reserve has a number of programs taught in conjunction with other University Circle institutions, including the Cleveland Clinic, the University Hospitals of Cleveland, the Louis Stokes Cleveland Department of Veteran's Affairs Medical Center, Cleveland Institute of Music, the Cleveland Hearing & Speech Center, the Cleveland Museum of Art, the Cleveland Institute of Art, the Cleveland Museum of Natural History, and the Cleveland Play House. Severance Hall, home of the Cleveland Orchestra, is on the Case Western Reserve campus.

Seventeen Nobel laureates have been affiliated with Case Western Reserve's faculty and alumni or one of its two predecessors.