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Dune is a science fiction media franchise that originated with the 1965 novel Dune by Frank Herbert and has continued to add new publications. Dune is frequently cited as the best selling science fiction novel in history. It won the inaugural Nebula Award for Best Novel in 1965 and the 1966 Hugo Award, and was later adapted into a 1984 film, a 2000 television miniseries, and a 2021 film. Herbert wrote five sequels, the first two of which were presented as a miniseries called Frank Herbert's Children of Dune in 2003. Dune has also inspired some traditional games and a series of video games. Since 2009, the names of planets from the Dune novels have been adopted for the real-world nomenclature of plains and other features on Saturn's moon Titan.

Frank Herbert died in 1986. Beginning in 1999, his son Brian Herbert and science fiction author Kevin J. Anderson published a number of prequel novels, as well as two sequels that complete the original Dune series (Hunters of Dune in 2006 and Sandworms of Dune in 2007), partially based on Frank Herbert's notes discovered a decade after his death.

The political, scientific, and social fictional setting of Herbert's novels and derivative works is known as the Dune universe or Duniverse. Set tens of thousands of years in the future, the saga chronicles a civilization that has banned all "thinking machines", which include computers, robots and artificial intelligence. In their place, civilization has developed advanced mental and physical disciplines as well as advanced technologies that adhere to the ban on computers. Vital to this empire is the harsh desert planet Arrakis, the only known source of the spice melange, the most valuable substance in the universe.

Due to the similarities between some of Herbert's terms and ideas and actual words and concepts in the Arabic language, as well as the series' "Islamic undertones" and themes, a Middle Eastern influence in Herbert's works has been noted repeatedly.