ACTIVE zone. The source of the North River in the Mesabi Range in MINNESOTA is considered to be the source of the Saint Lawrence River.Colorado river It is one of the principal rivers in the Southwestern United STATES and northern Mexico. The river drains a vast arid and semiarid sector of the North AMERICAN continent, and is often referred to as the “Lifeline of the Southwest”.Amazon river It is the largest river by discharge VOLUME of water in the world.The Amazon River is home to more than 5,600 known species of fish.The Amazon River dolphin is the largest species of river dolphin in the worldMackenzie river It is the longest river system in Canada and includes the second-largest drainage basin of any North American river after the Mississippi. It begins at Great Slave Lake in the Northwest Territories and flows north into the Arctic Ocean.