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H. Sophie Newcomb Memorial College, or Newcomb College, was the coordinate women's college of Tulane University located in New Orleans, in the U.S. state of Louisiana. It was founded by Josephine Louise Newcomb in 1886 in memory of her daughter.

Newcomb was the first women's coordinate college within a United States university. This model was later used in partnerships such as Pembroke College at Brown University and Barnard College at Columbia University.

In 2006, Newcomb College was closed as part of Tulane's Renewal Plan following the major losses and damage of Hurricane Katrina in 2005. Heirs of Mrs. Newcomb sued, challenging Tulane on the issue of donor intent and seeking to preserve Newcomb as a separate coordinate college within the university, but the lawsuit ended in 2011 after appellate court declined to rule on the case.