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Sephiroth (Japanese: セフィロス, Hepburn: Sefirosu) is a fictional character and the main antagonist of Final Fantasy VII developed by Square (now Square Enix). Character designer Tetsuya Nomura conceived and designed Sephiroth as an antagonist to—and direct physical opposite of—the game's main character, Cloud Strife. The character was voiced by voice actor Toshiyuki Morikawa in Japanese. In English, Sephiroth has been voiced by Lance Bass in Kingdom Hearts and by George Newbern in all subsequent appearances, with the exception of Final Fantasy VII Remake, where he is voiced by Tyler Hoechlin.

Sephiroth is later revealed to be the result of an experiment by the megacorporation Shinra, in which they injected him with cells from the extraterrestrial lifeform Jenova when he was still a fetus. Upon discovering this, Sephiroth decides to follow what he believes to be his destiny and take control of the Planet, while Cloud and the game's other protagonists attempt to stop him. Sephiroth's background and role in the story are expanded in the Compilation of Final Fantasy VII. Additionally, he appears as a guest character in other video games and media, such as a recurring boss in the Kingdom Hearts series and as a playable character in Super Smash Bros. Ultimate.

Sephiroth has been well-received within the video game community and is highly ranked on many lists of the best video game villains and Final Fantasy characters based on his role in the narrative and his high challenge level.