ANSWER is RPSQ. :-Here, Part R will be the first sentence because 'LITTLE did someone realize is a phrase used for saying that someone does not know/realize that something is true.For Example - Little did I realize I would one day be in charge of the office.The next part will start with the conjunction 'that' for introducing a SUBORDINATE clause expressing a STATEMENT or hypothesis.Let down - fail to support or help someone as they had hoped or expected.For Example - If I let him down now, I knew he'd never trust me again.Hence, Part P will be the next sentence.Then, the next part will contain the object of the sentence 'a colleague' who failed to help the subject of the sentence 'he' and the object will be preceded by a preposition 'by'. Therefore, Part S will be the next sentence. Lastly, Part Q will be used.Therefore, as per the points mentioned above, we find that the correct answer is Option 4. Correct Sentence: Little did he realise that he had been let down by a colleague whom he has STOOD by all these years.