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The Studio Museum in Harlem is an American art museum devoted to the work of artists of African descent. The Museum’s galleries are currently closed in preparation for a building project that will replace the current building, located at 144 West 125th Street between Adam Clayton Powell Jr. Boulevard and Lenox Avenue in Harlem, Manhattan, New York City, with a new one on the same site. Founded in 1968, the museum collects, preserves and interprets art created by African Americans, members of the African diaspora, and artists from the African continent. Its scope includes exhibitions, artists-in-residence programs, educational and public programming, and a permanent collection.

Since opening in a rented loft at Fifth Avenue and 125th Street, the Studio Museum has earned recognition for its role in promoting the works of artists of African descent. The Museum's Artist-in-Residence program has supported over one hundred graduates who have gone on to highly regarded careers. A wide variety of educational and public programs include lectures, dialogues, panel discussions and performances, as well as interpretive programs, both on- and off-site, for students and teachers. The exhibitions program has also expanded the scope of art historical literature through the production of scholarly catalogues, brochures, and pamphlets.