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The Powerpuff Girls is an American superhero animated television series created by animator Craig McCracken and produced by Hanna-Barbera (later Cartoon Network Studios) for Cartoon Network. The show centers on Blossom, Bubbles, and Buttercup, three kindergarten-aged girls with superpowers. The girls all live in the fictional city of Townsville with their father and creator, a scientist named Professor Utonium, and are frequently called upon by the city's mayor to help fight nearby criminals and other enemies using their powers.

McCracken originally developed the show in 1992 as a cartoon short entitled Whoopass Stew! while in his second year at CalArts. Following a name change, Cartoon Network featured the first Powerpuff Girls pilots in its animation showcase program World Premiere Toons in 1995 and 1996. The series made its official debut as a Cartoon Cartoon on November 18, 1998, with the final episode airing on March 25, 2005. A total of 78 episodes were aired in addition to two shorts, a Christmas special, a feature film, a tenth anniversary special, and a special episode using CGI technology. Various spin-off media include an anime, three CD soundtracks, a home video collection, comic books, a series of video games, a 2016 reboot series, as well as various licensed merchandise. The series has been nominated for six Emmy Awards, nine Annie Awards, and a Kids' Choice Award during its run.